LOW-FREQUENCY OF HLA-B27 AND SCARCITY OF ANKYLOSING-SPONDYLITIS IN A ZAIREAN BANTU POPULATION

Authors
MBAYO K MBUYIMUAMBA JM LURHUMA AZ HALLE L KAPLAN C DEQUEKER J
Citation
K. Mbayo et al., LOW-FREQUENCY OF HLA-B27 AND SCARCITY OF ANKYLOSING-SPONDYLITIS IN A ZAIREAN BANTU POPULATION, Clinical rheumatology, 17(4), 1998, pp. 309-310
Citations number
16
Categorie Soggetti
Rheumatology
Journal title
Clinical rheumatology → ACNP
ISSN journal
07703198
Volume
17
Issue
4
Year of publication
1998
Pages
309 - 310
Database
ISI
SICI code
0770-3198(1998)17:4<309:LOHASO>2.0.ZU;2-Z
Abstract
Ankylosing spondylitis (AS) is an inflammatory rheumatic disease which is thought to be rarely seen in African Blacks. Its genetic predispos ition has been stressed in Caucasians where the HLA-B27 antigen is fir mly linked to the disease. In the present study, HLA-B27 antigen was d etermined in 146 individuals of Bantu root. Only one of these subjects was found to possess HLA-B27 antigen. This study correlates the low f requency of HLA-B27 with the observed scarcity of AS in patients atten ding a clinic in Kinshasa for osteoarticular diseases.