SIMPLIFYING OVULATION INDUCTION FOR SURROGACY IN WOMEN WITH MAYER-ROKITANSKY-KUSTER-HAUSER-SYNDROME

A simple approach for ovulation induction in women with Mayer-Rokitans ky-Kuster-Hauser Syndrome (MRKH-S) during in-vitro fertilization (IVF) /freezing/surrogacy cycles was evaluated. Weekly progesterone plasma c oncentrations were measured in order to accurately establish the lutea l phase in MRKH-S women. When a rising titre was detected, a gonadotro phin-releasing hormone analogue (GnRHa) was administered as part of a long protocol, Two weeks later human menopausal gonadotrophin (HMG) th erapy was started. Ten treatment cycles in four women with MRKH-S were carried out. In all cases, three or less progesterone estimations wer e needed. Three of the four women are now through surrogacy, genetic m others; one of them has two children, We concluded that weekly determi nation of progesterone plasma concentration is a convenient, efficient and inexpensive simple approach to identify the luteal phase, and the refore suitable to the start of a GnRHa/ HMG protocol in MRKH-S women enrolled in an assisted reproduction technology programme.