WEIGHT-LOSS IN OBESE INFERTILE WOMEN RESULTS IN IMPROVEMENT IN REPRODUCTIVE OUTCOME FOR ALL FORMS OF FERTILITY TREATMENT

Obesity affects ovulation, response to fertility treatment, pregnancy rates and outcome, In this prospective study, a weight loss programme was assessed to determine whether it could help obese infertile women, irrespective of their infertility diagnosis, to achieve a viable preg nancy, ideally without further medical intervention, The subjects unde rwent a weekly programme aimed at lifestyle changes in relation to exe rcise and diet for 6 months; those that did not complete the 6 months were treated as a comparison group. Women in the study lost an average of 10.2 kg/m(2), with 60 of the 67 anovulatory subjects resuming spon taneous ovulation, 52 achieving a pregnancy (18 spontaneously) and 45 a live birth. The miscarriage rate was 18%, compared to 75% for the sa me women prior to the programme. Psychometric measurements also improv ed. None of these changes occurred in the comparison group. The cost s avings of the programme were considerable. Prior to the programme, the 67 women had had treatment costing a total of A$550 000 for two live births, a cost of A$275 000 per baby. After the programme, the same wo men had treatment costing a total of A$210 000 for 45 babies, a cost o f A$4600 per baby. Thus weight loss should be considered as a first op tion for women who are infertile and overweight.