A RANDOMIZED COMPARISON OF THE METHODS OF SPERM PREPARATION FOR INTRAUTERINE INSEMINATION

Objective: To compare the effectiveness of three methods of sperm prep aration for IUI during superovulation of infertile women. Design: Rand omized assignment of one of three sperm preparation methods. Setting: University infertility practice. Patient(s): Infertile couples undergo ing superovulation and IUI. Intervention(s): The method of preparation of sperm for IUI during superovulation was assigned randomly to doubl e centrifugation, multiple-tube swim-up, or Percoll density gradient. Main Outcome Measure(s): Total number and percent recovery of motile s perm, percent of recovered sperm with normal morphology, and cycle fec undity. Result(s): No method of sperm preparation provided better cycl e fecundity than the others despite differences in sperm recovery. Con clusion(s): Double centrifugation, multiple-tube swim-up, and Percoll density gradient sperm preparation for IUI yield similar cycle fecundi ty rates. (Fertil Steril(R) 1998;70:574-5. (C) 1998 by American Societ y for Reproductive Medicine.).