REFINED RADIATION HYBRID MAP OF MOUSE-CHROMOSOME-17

We have made a radiation hybrid map of mouse Chromosome (Chr) 17 with 75 microsatellite markers, including those from McCarthy et al. (Genom e Res 7, 1153-1161, 1997). Seventy-four of the markers are linked at L OD > 9, and all link at LOD > 5. A LOD 3 framework of 18 markers was u sed to construct a placement map. The order obtained is in good agreem ent with genetic maps, and distance estimates give an idea of how reco mbination rates vary across the chromosome. Recombination is remarkabl y low with respect to RH break frequency in the region from the centro mere to the end of H2. This is similar in interspecific and intersubsp ecific crosses despite the inversion of a substantial part of this reg ion in Mus spretus with respect to Mus musculus.