A. Zuppiroli et al., A FAMILY STUDY OF ANTERIOR MITRAL LEAFLET THICKNESS AND MITRAL-VALVE PROLAPSE, The American journal of cardiology, 82(6), 1998, pp. 823
To determine whether mitral valve prolapse (MVP) with or without mitra
l leaflet thickening (greater than or equal to 5 mm) represents distin
ct heritable conditions, 13 patients with MVP with leaflet thickening
and their relatives were compared with 67 patients with MVP with norma
l leaflets and their relatives. The 2 groups of relatives had similar
mitral leaflet thicknesses and similar longterm outcome, arguing again
st the existence of a distinctive subtype of MVP characterized by incr
eased mitral leaflet thickness.