Gluon depletion in the collision of large nuclei can result in a signi
ficant reduction in the c (c) over bar production rate. It may be the
mechanism that is responsible for the observed J/psi suppression in he
avy-ion collisions. The nonlinear effect due to multiple scatterings a
mong comoving partons initiated by primary scattering of partons can a
ccount for the enhanced suppression in the Pb-Pb data.