THE INFLUENCE OF WATER ACTIVITY ON THE ENANTIOSELECTIVITY IN THE ENZYME-CATALYZED REDUCTION OF 2-PENTANONE

Authors
JONSSON A VANBREUKELEN W WEHTJE E ADLERCREUTZ P MATTIASSON B
Citation
A. Jonsson et al., THE INFLUENCE OF WATER ACTIVITY ON THE ENANTIOSELECTIVITY IN THE ENZYME-CATALYZED REDUCTION OF 2-PENTANONE, Journal of molecular catalysis. B, Enzymatic, 5(1-4), 1998, pp. 273-276
Citations number
12
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis. B, Enzymatic → ACNP
ISSN journal
13811177
Volume
5
Issue
1-4
Year of publication
1998
Pages
273 - 276
Database
ISI
SICI code
1381-1177(1998)5:1-4<273:TIOWAO>2.0.ZU;2-9
Abstract
The stereoselective reduction of 2-pentanone by alcohol dehydrogenase from Thermoanaerobium brockii was studied at controlled water activity and at different reaction temperatures. The reaction rate increased w hen water activity was increased from 0.32 to 0.96 and when raising th e temperature from 5 degrees C to 40 degrees C. The enantioselectivity , E, reached a plateau value at high water activities. The enantiosele ctivity increased with decreasing reaction temperature. (C) 1998 Elsev ier Science B.V. All rights reserved.