LIPASE-CATALYZED TRANSESTERIFICATION OF 2-SUBSTITUTED 3-HYDROXY ESTERS

Authors
KAGA H HIROSAWA K TAKAHASHI T GOTO K
Citation
H. Kaga et al., LIPASE-CATALYZED TRANSESTERIFICATION OF 2-SUBSTITUTED 3-HYDROXY ESTERS, Chirality, 10(7), 1998, pp. 693-698
Citations number
10
Categorie Soggetti
Chemistry Medicinal","Chemistry Analytical","Chemistry Inorganic & Nuclear","Pharmacology & Pharmacy
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
10
Issue
7
Year of publication
1998
Pages
693 - 698
Database
ISI
SICI code
0899-0042(1998)10:7<693:LTO23E>2.0.ZU;2-Y
Abstract
Kinetic resolution of 2-substituted 3-hydroxy esters was examined by l ipase PS catalyzed transesterification using vinyl acetate as an acyl donor. Resolution of (+/-)-syn- and -anti-1a, -1e possessing a small m ethyl group at the C-3 position was accomplished enantioselectively. T he outcome of the resolution seems to be related to the differences in size of the substituents at the stereocenter bearing a secondary hydr oxy group. (C) 1998 Wiley-Liss, Inc.