EFFECTS OF DIETARY METHIONINE AND CYSTINE ON LIPID-METABOLISM IN HEPATOMA-BEARING RATS WITH HYPERLIPIDEMIA

Abnormal lipid metabolism and its restoration by dietary methionine (M et) and cystine (Cys) were studied io Donryu rats subcutaneously impla nted with an ascites hepatoma cell line of AH109A. The hepatoma-bearin g rats exhibited hyperlipidemia characterized by rises in serum trigly ceride and cholesterol levels. Decreased lipoprotein lipase (LPL) acti vities in epididymal adipose tissue, cardiac muscle, and gastrocnemius as well as increased fatty acid mobilization from adipose tissue were considered to be responsible for the hepatoma-induced hypertriglyceri demia, while increased hepatic cholesterogenesis and decreased steroid excretion into feces were thought to he responsible for the hepatoma- induced hypercholesterolemia. Dietary-supplemented Met or Cys reduced the AH109A-induced hypertriglyceridemia with suppression of fatty acid synthesis in the host liver. Met restored the fall of LPL activities, while Cys did not. Dietary Met or Cys also reduced the hypercholester olemia with restoration of decreased bile acid excretion into feces. T hese results suggest that dietary Met or Cys is hypolipidemic in the h epatoma-bearing rats with slight differences in their modes of action.