CYCLODEXTRIN INCLUSION COMPLEXES WITH VITAMIN-D-3 - INVESTIGATIONS OFTHE SOLID COMPLEX CHARACTERIZATION

and safe use of vitamin D-3 in pharmaceutical and food industries requ ires imperatively to solve the problem of its stability and its disper sion within complex matrices such as drugs and foodstuffs. Inclusion c omplex formation with cyclodextrins seems to be the best solution. At industrial scale, the final product is a solid form. We investigated U V/VIS spectrophotometry, infrared spectroscopy, H-1 and C-13 nuclear m agnetic resonance, mass spectrometry and X-ray diffraction in order to determine the most appropriate technique for the characterization of the solid inclusion complex of vitamin D-3 by either beta-cyclodextrin or gamma-cyclodextrin and we used molecular modeling under GENMOL(R) to continue to explore the inclusion of vitamin Dg and its most import ant metabolite in these cyclodextrins.