Objective: To review the physics related to the holmium laser, its las
er-tissue interactions, and its application to the treatment of urolog
ical diseases. Summary and Background Data: The holmium:YAG laser is a
solid-state, pulsed laser that emits light at 2100 nm, It combines th
e qualities of the carbon dioxide and neodymium:YAG lasers providing b
oth tissue cutting and coagulation in a single device, Since the holmi
um wavelength can be transmitted down optical fibers, it is especially
suited for endoscopic surgery. Methods: The authors provide a review
of the literature as it relates to the holmium laser and its applicati
on to urology. Results: The holmium wavelength is strongly absorbed by
water. Tissue ablation occurs superficially, providing for precise in
cision with a thermal injury zone ranging from 0.5 to 1.0 mm, This lev
el of coagulation is sufficient for adequate hemostasis, The most comm
on urologic applications of the holmium laser that have been reported
include incision of urethral and ureteral strictures; ablation of supe
rficial transitional cell carcinoma; bladder neck incision and prostat
e resection; and lithotripsy of urinary calculi, Conclusions: The holm
ium:YAG laser is a multi-purpose, multi-specialty surgical laser, It h
as been shown to be safe and effective for multiple soft tissue applic
ations and stone fragmentation. Its utilization in urology is anticipa
ted to increase with time as a result of these features.