Objective: The authors review the current knowledge regarding the appl
ication of the Holmium:YAG laser for prostatectomy, Summary Background
Data: Conventional surgical therapies for benign prostatic hyperplasi
a (BPH) are effective but associated with relatively high morbidity, L
aser prostatectomy, using either Neodymium:YAG or potassium-titanyl-ph
osphate lasers, has emerged as a new and much safer operative approach
to relieve symptoms of benign prostatic hyperplasia. However, these l
aser wavelengths possess key disadvantages that have limited their acc
eptability and dissemination in everyday urologic practice. Methods: T
he authors review their own extensive experience in the development an
d clinical application of Holmium:YAG laser technology for prostatecto
my, as well as the published reports in the current medical literature
now dealing with this subject. Results: In multiple clinical trials,
Holmium:YAG laser resection of the prostate has proven efficacious in
relieving symptomatic BPH, Both objective urodynamic measures of voidi
ng outcomes and symptomatic improvement have been shown to be equivale
nt to standard electrocautery resection of the prostate, At the same t
ime, these studies have demonstrated the superior safety and hemostasi
s of Holmium:YAG laser prostatectomy compared to electrocautery resect
ion, similar to prior laser prostatectomy procedures, Unlike prior for
ms of laser prostatectomy, Holmium:YAG laser resection of the prostate
acutely removes all obstructing prostate tissue, so that the postoper
ative catheterization requirement is typically only overnight and impr
ovement in voiding is immediate, Current operative techniques and the
latest technological developments to facilitate Holmium:YAG laser pros
tatectomy are described. Conclusions: Holmium:YAG laser prostatectomy
combines the best features of prior laser prostatectomy technologies,
including minimal complications and morbidity, with the efficacy and i
mmediacy of voiding outcomes associated with conventional electrocaute
ry resection of the prostate.