EFFECT OF RECOMBINANT HUMAN INSULIN-LIKE GROWTH-FACTOR-I ON EXPRESSION OF GLUCOSE TRANSPORTERS, GLUT-2 AND GLUT-4, IN STREPTOZOTOCIN-DIABETIC RAT

Authors
ASADA T OGAWA T IWAI M KOBAYASHI M
Citation
T. Asada et al., EFFECT OF RECOMBINANT HUMAN INSULIN-LIKE GROWTH-FACTOR-I ON EXPRESSION OF GLUCOSE TRANSPORTERS, GLUT-2 AND GLUT-4, IN STREPTOZOTOCIN-DIABETIC RAT, Japanese Journal of Pharmacology, 78(1), 1998, pp. 63-67
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Japanese Journal of Pharmacology → ACNP
ISSN journal
00215198
Volume
78
Issue
1
Year of publication
1998
Pages
63 - 67
Database
ISI
SICI code
0021-5198(1998)78:1<63:EORHIG>2.0.ZU;2-G
Abstract
We investigated the effect of recombinant insulin-like growth factor-I (rhIGF-I) on the expression of glucose transporters, GLUT 2 in the li ver and GLUT 4 in the heart, in streptozotocin (STZ)-diabetic rats by the reverse transcription-polymerase chain reaction (RT-P CR) and immu nohistochemistry. GLUT 2 and its mRNA in the liver was elevated, where as GLUT 4 and its mRNA in the heart were decreased in STZ-diabetic rat s. A two-week treatment with rhIGF-I mostly restored the expression of GLUT 2 and GLUT 4 to normal rat level. We demonstrated that the effec t of IGF-I on the expressions of GLUTs was almost the same as that of insulin.