PRODUCTION OF SUPEROXIDE AND NITRIC-OXIDE BY ALVEOLAR MACROPHAGES IN THE BLEOMYCIN-INDUCED INTERSTITIAL PNEUMONIA MICE MODEL

Authors
YAMAZAKI C HOSHINO J SEKIGUCHI T HORI Y MIYAUCHI S MIZUNO S HORIE K
Citation
C. Yamazaki et al., PRODUCTION OF SUPEROXIDE AND NITRIC-OXIDE BY ALVEOLAR MACROPHAGES IN THE BLEOMYCIN-INDUCED INTERSTITIAL PNEUMONIA MICE MODEL, Japanese Journal of Pharmacology, 78(1), 1998, pp. 69-73
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Japanese Journal of Pharmacology → ACNP
ISSN journal
00215198
Volume
78
Issue
1
Year of publication
1998
Pages
69 - 73
Database
ISI
SICI code
0021-5198(1998)78:1<69:POSANB>2.0.ZU;2-T
Abstract
To elucidate the potential role of superoxide (O-2(-)) and nitric oxid e (NO) in the pathogenesis of interstitial pneumonia, the quantity of O-2(-) and NO produced by the alveolar macrophages (AM) were determine d in the bleomycin (BLM)-induced interstitial pneumonia mouse model. T he production of O-2(-) and NO increased on days 7, 14 and 21 after BL M injection. Strong expression of peroxynitrite (ONOO-) was seen in AM by using immunostaining for nitrotyrosine. The hydroxyproline content s increased on day 21 after BLM injection. O-2(-) and NO are thought t o play an important role in the pathology of fibrosis.