Although fertilization has been studied for more than a century, the c
ell surface proteins mediating the process are only now becoming known
. Gamete interaction in animals appears to be molecularly complex. Alt
hough it is difficult to generalize at present, diversity of structure
may be a recurring theme in the evolution of fertilization proteins.
Examples of rapid evolution of fertilization proteins by positive sele
ction are known, and concerted evolution call influence the differenti
ation of gamete recognition proteins between closely related species.