GASTRIC FOVEOLAR IMMATURE CELLS (MUCOPEPTIC CELLS) EXPANSION IN BODY-FUNDIC ADVANCED INTESTINAL-TYPE GASTRIC-CANCER IN PATIENTS WITH CHRONIC NON-ATROPHIC (SUPERFICIAL) GASTRITIS - HELICOBACTER-PYLORI ROLE

Background, Some authors reported the relationship between Helicobacte r pylori (HP) prevalence and gastric cancer incidence, It is generally agreed that RP plays a key role in altering regulatory factors affect ing cellular proliferation during the disease process. This hyperproli feration is due, mainly, to active inflammation action on glandular ne ck cells. Neoplastic changes may arise owing to a loss of control of c ell proliferation, Methods. In the present study it has been evaluated the muco-peptic cells (immature cells) expansion in surrounding areas of body-fundic intestinal type advanced gastric cancer (GC) in patien ts with non atrophic gastritis: the cases have been subdivided in rela tion with HP infection. Results, Muco-peptic expansion was present in 73.9% of HP positive GC patients. The cell expansion has not been obse rved either in HP negative GC or in control subjects. Conclusions. The phenomenon, a morphological manifestation of hyperproliferation, migh t overexpose the mucosa to environmental factors. Therefore, in subjec ts with genetic predisposition, RP could act as a promoter in the prog ression towards neoplasia independently of chronic atrophic gastritis.