This issue of New Horizons is about change. While our traditional appr
enticeship model of physician training has served us well, adaptation
is required for the new millennium. Among several sectoral trends in m
edicine, two are particularly relevant for intensivists: a) the inform
ation explosion and b) increased accountability to society regarding e
ffective, efficient, compassionate, and culturally sensitive care. Evi
dence-based medicine (EBM) (or any other single initiative, for that m
atter) is not going to address all of tomorrow's challenges. However,
EBM does help by enhancing clinical informatics and critical appraisal
skills so that clinicians are better able to keep up with the growing
literature, and decide whether, and if so, this literature applies to
individual patients. In addition, EBM can help to highlight the deter
minants of clinical decisions, which may include contributions of care
giver knowledge, patient pathophysiology, research evidence, patient a
nd societal values, and increasingly, costs. While EBM is best practic
ed at the individual level, its application to other aspects of health
care is growing.