ANTIINFLAMMATORY ACTIVITY OF LONICERA-JAPONICA

As part of our investigations into new antiinflammatory agents based o n plant extracts, the n-butanol (BuOH) fraction of Lonicera japonica w as prepared and its antiinflammatory activity was evaluated using seve ral experimental animal models of inflammation. At oral doses of 100-4 00 mg/kg, the BuOH fraction showed antiinflammatory activity against a cute, granulomatic and chronic inflammation models in mice and rats. A lthough the activity was not potent compared with prednisolone, the re sults support the traditional use and suggest that this fraction of L, japonica may yield a safe and mild antiinflammatory agent for treatin g various inflammatory disorders, (C) 1998 John Wiley & Sons, Ltd.