PRODUCTION OF (R)-2-BROMO-5-PHTHALIMIDOPENTANOIC ACID VIA A DIAZOTIZATION PROCESS FROM (R)-ORNITHINE

Authors
BUNEGAR MJ DYER UC GREEN AP GOTT GG JAGGS CM LOCK CJ MEAD BJV SPEARING WR TIFFIN PD TREMAYNE N WOODS M
Citation
Mj. Bunegar et al., PRODUCTION OF (R)-2-BROMO-5-PHTHALIMIDOPENTANOIC ACID VIA A DIAZOTIZATION PROCESS FROM (R)-ORNITHINE, Organic process research & development, 2(5), 1998, pp. 334-336
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
2
Issue
5
Year of publication
1998
Pages
334 - 336
Database
ISI
SICI code
1083-6160(1998)2:5<334:PO(AVA>2.0.ZU;2-O
Abstract
A scaleable ''one-pot'' preparation of (R)-2-bromo-5-phthal-imidopenta noic acid from (R) ornithine is described. The use of this chirality p ool method allowed for rapid development of the process. Acetic acid w as found to be an efficient antifoaming agent during the diazotisation reaction. The use of an extractive workup procedure has the benefit o f reducing operator exposure to the corrosive reaction mixture and min imised manual handling operations.