INVESTIGATION OF SELECTIVELY SUBSTITUTED MONOSACCHARIDES BY THE METHOD OF VIBRATIONAL SPECTROSCOPY AND X-RAY-ANALYSIS

The influence of steric factors on the formation of vibrational spectr a of carbohydrates was illustrated by the example of selectively subst ituted monosaccharides. We consider compounds in which the difference and similarity of vibrational spectra are largely determined by the di fference and similarity of the geometry of their molecular base (the m olecule's skeleton). At the same time, in the case of selectively subs tituted nitrates of methyl-P-D-glucopyranoside, the skeletal bases of which are identical, with differences in the localization site of volu metric substituents and their total number, or in rotational isomers ( conformations) of the lateral nitrate groups, their Fourier Raman spec tra are different over a wide spectral range. It is concluded that ste ric factors and the position of volumetric substituents of hydroxyls p roduce an exceptionally important effect on the formation of vibration al spectra of carbohydrates. (C) 1998 Elsevier Science B.V.