CHRONIC LOW-DOSE LESION EQUILIBRIUM ALONG GENES - MEASUREMENT, MOLECULAR EPIDEMIOLOGY, AND THEORY OF THE MINIMAL RELEVANT DOSE

Authors
HOLMQUIST GP
Citation
Gp. Holmquist, CHRONIC LOW-DOSE LESION EQUILIBRIUM ALONG GENES - MEASUREMENT, MOLECULAR EPIDEMIOLOGY, AND THEORY OF THE MINIMAL RELEVANT DOSE, Mutation research. Fundamental and molecular mechanisms of mutagenesis, 405(2), 1998, pp. 155-159
Citations number
13
Categorie Soggetti
Genetics & Heredity",Toxicology,"Biothechnology & Applied Migrobiology
Journal title
Mutation research. Fundamental and molecular mechanisms of mutagenesis
ISSN journal
13861964 → ACNP
Volume
405
Issue
2
Year of publication
1998
Pages
155 - 159
Database
ISI
SICI code
1386-1964(1998)405:2<155:CLLEAG>2.0.ZU;2-9
Abstract
Spontaneous mutations seem to be caused almost entirely by endogenous lesions. The pattern of these lesions along a gene represents an equil ibrium between damage and repair. A pattern can be measured using liga tion-mediated PCR (polymerase chain reaction) and a large chronic dose of a suspected endogenous mutagen. A study using dimethylsulfate-indu ced 7(me)Guanine lesions indicates that the exogenously induced patter n depends on how methyl purine glycosylase recognizes sequence context and, for this lesion, the pattern may be independent of the mutagen's dose. (C) 1998 Elsevier Science B.V. All rights reserved.