NEUROHORMONAL CONTROL OF THE EXOCRINE PANCREAS

This review updates our progress in understanding the neurohormonal co ntrol of the exocrine pancreatic secretion. Major advances include cla rification of factors in the duodenum that are important for the relea se of cholecystokinin (CCK), the pathways of CCK's pancreatic enzyme s ecretory actions, cholinergic augmentation of the actions of secretin, and the role of central and peripheral nerves in controlling pancreat ic secretion. Progress has also been made in identifying neurotransmit ters and hormonal factors that modulate pancreatic secretion at centra l and peripheral sites, including serotonin, dopamine, pancreatic poly peptide, somatostatin, and glucagon-like peptide-1. These findings con tinue the revolution in understanding pancreatic control mechanisms.