Emergency treatment of bleeding ulcer of the duodenum is endoscopy and
endoscopic blood-staunching. In high-risk patients with Forrest Ia le
sions or ulcers with visible vessel (Forrest Ia) endoscopic follow-up
or early elective operation is required. Fibrin sealing can improve th
e results of endoscopic injection therapy for bleeding ulcer. Neverthe
less, severe complications such as secondary perforation of the fibrin
clot or recurrent bleeding can occur. Identification of highrisk pati
ents and complications requires close monitoring and attention. A case
of a secondary perforation of a bleeding ulcer of the duodenum after
fibrin sealing is reported.