DIFFERENCES IN CARDIOVASCULAR ADAPTATIONS TO ENDURANCE EXERCISE TRAINING BETWEEN OLDER MEN AND WOMEN

Recent studies have shown that people in their seventh decade are able to adapt to exercise training with an increase in maximal O2 uptake ( Vo2max) similar in relative magnitude to that observed in young people . The purpose of this study was to determine the relative contribution s of increases in stroke volume and O2 extraction to the training-indu ced increase in Vo2max. in older men and women. Fifteen men [63 +/- 3 (SE) yr] and 16 women (64 +/- 3 yr), in good health, participated in 9 -12 mo of endurance exercise training at 70 to 85% of maximal heart ra te for 45 min/day, 4 days/wk. Vo2max increased 19% (2.35 +/- 0.1 to 2. 8 +/- 0.1 l/min; P < 0.01) in the men and 22% (1.36 +/- 0.1 to 1.66 +/ - 0.1 l/min; P < 0.01) in the women in response to training. In the me n, stroke volume during maximal exercise was 15% higher after training , and this increase accounted for 66% of the increase in Vo2max. The r emainder of the increase in Vo2max was accounted for by a 7% greater a rteriovenous O2 content difference during maximal exercise. In contras t, training resulted in no change in stroke volume in women, in whom t he entire increase in Vo2max was accounted for by a greater arterioven ous O2 content difference (12.2 +/- 0.4 before vs. 14.4 +/- 0.4 ml O2/ 100 ml blood after; P < 0.01) during maximal exercise. There were no c hanges in these variables in the control subjects. The mechanisms resp onsible for the training-induced increase in Vo2max in the older men w ere similar to those found in young people. However, the older women a dapted to the exercise training with an increase in O2 extraction with no increase in cardiac output.