SYNUCLEINS - KEYS TO THE MECHANISMS OF NEURODEGENERATIVE DISEASES

The synuclein family is a group of evolutionarily conserved proteins p roduced mainly in the nervous system. Synucleins are involved in the p athogenesis of human neurodegenerative disorders, first of all Parkins on's and Alzheimer's diseases. The review considers the structure of s ynucleins and their role in the development and functioning of the ner vous system, the structural alterations in synucleins, and the probabl e mechanisms of their functional impairment that can lead to pathologi es of the central and peripheral nervous systems.