QUANTIFICATION OF THE EXTRACTION FRACTION FOR GADOPENTETATE ACROSS BREAST-CANCER CAPILLARIES

To quantify the extraction fraction, E, for gadopentetate across tumor capillaries, R3230 adenocarcinomas were implanted in the mammary fat pads of seven rats, The value of E was determined by using a two-compa rtment tissue model in which the endothelial transfer coefficient, K-P S (ml.min(-1).cc(-1) of tissue), was estimated from the model fitted t o changes in R-1 relaxation time (Delta R-1; s(-1)) measured by dynami c three-dimensional spoiled gradient recalled magnetic resonance imagi ng after injection of 0.1 mmol.kg(-1) of gadopentetate dimeglumine, Th e plasma flow rate through the tumor capillaries, F-p, (ml.min(-1).g(- 1) of tissue), was independently measured with fluorescent microsphere s. E could be calculated by the relationship, E = K-PS/F-p. The mean E for gadopentetate in the R3230 tumor was 0.197 +/- 0.118 with a range of 0.123-0.454. The relatively small mean value of E for gadopentetat e allows a fair approximation of the permeability surface area product by K-PS in this R3230 tumor model.