Forty-three adolescents qualifying for a DSM-III-R diagnosis of alcoho
l abuse/dependence were classified according to the internalizing-exte
rnalizing behavior dimension. Two clusters were identified. The majori
ty of subjects clustered into a group characterized by behavioral dysc
ontrol and hypophoria (history of suicide attempts) (cluster 2), where
as the other group was primarily featured by negative affect (cluster
1). Cluster 2 subjects demonstrated more severe alcohol and drug use-r
elated problems, behavioral disturbances, and general psychopathology;
lower prevalence of depressive disorders; and less severe anxiety dis
orders. These results, implicating two variants of adolescent alcohol
abuse/dependence, suggest the need to tailor differential treatments t
o adolescents with alcohol abuse/dependence based on personality chara
cteristics and clinical presentation.