EMPIRICAL ANTIBIOTIC-THERAPY IN PATIENTS WITH ACUTE-LEUKEMIA - RESULTS OF A MULTICENTER TRIAL

Aim. To evaluate efficacy of ampicilline/sulbactame and fluconasole in the regimen of empirical antibiotic therapy in patients with acute le ukemia. Materials and methods. The trial covered 14 hematological depa rtments of Russia and 1 of Ukrain. Acute myeloid leukemia patients wer e included. 92 cases of fever in 56 patients with analysis of efficacy in 66 cases were considered. At the first stage of empirical antibiot ic therapy, cefoperason (4 g/day) and gentamycin (240 mg/day) were adm inistered. If no response was reached, ampicilline/sulbactam (7.5 g/da y) was added. This was the second stage. If no response occurred for 5 days the three drugs were joined by fluconasol (400 mg followed by 20 0 mg). Results. Fever of unclear genesis was cured in 82% (28 of 34), clinical infection - in 80% (20 of 25), microbiologically confirmed in fection - in 4 of 7 cases. A complete response to the empirical antibi otic therapy was registered in 52 of 66 cases (79%). 7(10.5%) patients died of infectious complications. 7(10.5%) received other antibiotics .