FACTORS OF HEREDITARY PREDISPOSITION TO LYMPHOGRANULOMATOSIS

Aim. To determine genetic factors of predisposition marked HLA with re ference to serological and molecular characteristics. Materials and me thods, Four groups of patients were included in the study: 51 patients with lymphogranulomatosis (LGM), 33 healthy relatives of these patien ts, 37 patients with chronic myeloid leukemia (CML), 24 healthy relati ves of these CML patients. 224 donors sewed control. HLA-antigens were identified with the lymphocytotoxic test and PSR-MSSR. Results of typ ing of class II antigens were taken into consideration in coincidence of serological and DNA typing. The significance of the differences was estimated according to the chi-square criterion. Results. Differences in frequency of distribution of HLA-antigens (subloci A and B) were n ot found. Antigen CW7 was present in 70, DR5 in 60, DR6 in 50% of LGM patients. This frequency was much higher than in control groups. Carri ers of CW7 are at 7 times higher risk to develop LGM. Among LGM patien ts the number of homozygous individuals is higher than in healthy ones (50 and 15.6%) while the number of individuals with a complete set of HLA-A.B antigens is significantly less. Conclusion, Genetic predispos ition to LGM is predetermined by HLA antigens CW7, DR5, DR6. Genes HLA -DR1 and HLA-DR7 protect carriers from factors provoking LGM. Common H LA genes in the parents predispose their children to LGM. Insufficienc y of the phenotype is a factor predisposing to LGM.