HEMATOPOIETIC-CELLS TRANSPLANTATION IN PATIENTS WITH SOLID TUMORS

Aim. Evaluation of efficiency of bone marrow and peripheral stem cells transplantation in patients with solid tumors. Materials and methods. A total of 38 patients aged 30-40 years with stage III or IV solid tu mors (15 cases of breast cancer, 5 cases of Ewing's sarcoma, 4 cases o f osteogenic sarcoma, ovarian or testicular tumors, 3 cases of soft ti ssue sarcoma) underwent high-dose polychemotherapy with autologous hem atopoietic rescue. All the patients were resistant to the first line c hemotherapy or were in relapse of the disease. 21, 11 and 6 patients w ere transplanted bone marrow, peripheral blood stem cells and both bon e marrow and peripheral blood stem cells, respectively. Results. The o nly factor which influenced overall survival of the patients was the s tage of the disease at the moment of the transplantation. 66% of patie nts in complete or partial remission survived 3 years versus 16.6% of those in progression or relapse of the disease. Other parameters such as the patients' age, the sourse of hemopoietic cells, number of chemo therapy courses were not essential for the survival. 2 patients died a fter transplantation. The main cause of death was relapse or progressi on of the disease after the transplantation. Conclusion. Transplantati on of hemopoietic cells is a promising therapy of patients with solid tumors sensitive to chemotherapy.