TREATING ECTOPIC PREGNANCY WITH THE COMBINATION OF MIFEPRISTONE AND METHOTREXATE - A PHASE-II NONRANDOMIZED STUDY

OBJECTIVE: Our goal was to compare the use of a combination of methotr exate and mifepristone with methotrexate alone in the medical manageme nt of ectopic pregnancy. STUDY DESIGN: This was a preliminary nonrando mized phase II study. All patients with progressing ectopic pregnancy meeting criteria for medical management were included. Treatment consi sted of 50 mg/m(2) of methotrexate injected intramuscularly and 600 mg of mifepristone, administered orally, compared with a previous group who received only 50 mg/m2 of methotrexate injected intramuscularly. R ESULTS: Of the 30 patients treated with the combination, there was onl y 1 failure, whereas medical treat ment had failed for 11 of 42 patien ts treated with methotrexate alone. CONCLUSIONS: The combination of mi fepristone and methotrexate decreased the risk of failure in medical t reatment of ectopic pregnancy.