PATHOGENICITY OF AN ENTEROTOXIGENIC ESCHERICHIA-COLI HEMOLYSIN (HLYA)MUTANT IN GNOTOBIOTIC PIGLETS

Authors
MOXLEY RA BERBEROV EM FRANCIS DH XING J MOAYERI M WELCH RA BAKER DR BARLETTA RG
Citation
Ra. Moxley et al., PATHOGENICITY OF AN ENTEROTOXIGENIC ESCHERICHIA-COLI HEMOLYSIN (HLYA)MUTANT IN GNOTOBIOTIC PIGLETS, Infection and immunity, 66(10), 1998, pp. 5031-5035
Citations number
45
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
10
Year of publication
1998
Pages
5031 - 5035
Database
ISI
SICI code
0019-9567(1998)66:10<5031:POAEEH>2.0.ZU;2-N
Abstract
Pigs infected with hemolytic F4(+) strains of enterotoxigenic Escheric hia coli often develop septicemia secondary to intestinal infection. W e tested the hypothesis that inactivation of hemolysin would reduce th e ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural g ene (hlyA) did not decrease the incidence of septicemia in the gnotobi otic piglet model.