QSAR OF FLAVYLIUM SALTS AS INHIBITORS OF XANTHINE-OXIDASE

Authors
AMIC D DAVIDOVICAMIC D BESLO D LUCIC B TRINAJSTIC N
Citation
D. Amic et al., QSAR OF FLAVYLIUM SALTS AS INHIBITORS OF XANTHINE-OXIDASE, Journal of chemical information and computer sciences, 38(5), 1998, pp. 815-818
Citations number
19
Categorie Soggetti
Computer Science Interdisciplinary Applications","Computer Science Information Systems","Computer Science Interdisciplinary Applications",Chemistry,"Computer Science Information Systems
Journal title
Journal of chemical information and computer sciences → ACNP
ISSN journal
00952338
Volume
38
Issue
5
Year of publication
1998
Pages
815 - 818
Database
ISI
SICI code
0095-2338(1998)38:5<815:QOFSAI>2.0.ZU;2-P
Abstract
A simple QSAR model of xanthine oxidase (XO) inhibitory flavylium salt s, which enables prediction of the inhibitory potency of anthocyanidin s as a function of their molecular properties, has been developed. The results obtained in the present work help to understand which of the several tautomeric anhydrobase species present in nearly neutral solut ion are mainly responsible for the inhibition of XO.