EVALUATION OF RENAL HEMODYNAMICS IN AWAKE AND ISOFLURANE-ANESTHETIZEDCATS WITH PULSED-WAVE DOPPLER AND QUANTITATIVE RENAL SCINTIGRAPHY

The feasibility and reproducibility of obtaining the pulsed-wave Doppl er measurements of resistive index (RI) and pulsatility index (PI) wer e investigated in intrarenal arteries of normal, nonsedated cats, and cats anesthetized with isoflurane, In addition, relative renal functio n and relative renal blood flow were evaluated using quantitative rena l scintigraphy, The percentage of injected dose uptake, time to peak a ctivity, and two indices of renal blood flow (K/A ratio and flow index ) obtained during the first pass of Tc-99m-MAG(3), were determined for both awake and anesthetized cats. Results indicate that measuring RI and PI in nonsedated cats is readily accomplished and that the results are reproducible within an animal. Mean RI and PI values in the awake cats were 0.55 and 0.8, respectively. Significant differences between the awake and anesthetized cats were found for all pulsed-wave Dopple r and quantitative renal scintigraphic measurements evaluated.