Dg. Gilchrist, PROGRAMMED CELL-DEATH IN PLANT-DISEASE - THE PURPOSE AND PROMISE OF CELLULAR SUICIDE, Annual review of phytopathology, 36, 1998, pp. 393-414
The interaction of pathogens with plants leads to a disruption in cell
ular homeostasis, often leading to cell death, in both compatible and
incompatible relationships. The mechanistic basis of this cellular dis
ruption and consequent death is complex and poorly characterized, but
it is established that host responses to pathogens are dependent on ge
ne expression, involve signal transduction, and require energy. Recent
data suggest that in animals, a genetically regulated, signal transdu
ction-dependent programmed cell death process, commonly referred to as
apoptosis, is conserved over a wide range of phyla. The basic functio
n of apoptosis is to direct the selective elimination of certain cells
during development, but it also is a master template that is involved
in host responses to many pathogens. Programmed cell death in plants,
while widely observed, has not been studied extensively at either the
biochemical or genetic level. Current data suggest that activation or
suppression of programmed cell death may underlie diseases in plants
as it does in animals. This review describes some of the fundamental c
haracteristics of apoptosis in animals and points to a number of conne
ctions to programmed cell death in plants that may lead to both a bett
er understanding of disease processes and novel strategies for enginee
ring disease resistance in plants.