Recent advances in the understanding of the chemical processes that oc
cur during all stages of the formation of stars, from the collapse of
molecular clouds to the assemblage of icy planetesimals in protoplanet
ary accretion disks, are reviewed. Observational studies of the circum
stellar material within 100-10,000 AU of the young star with (sub)mill
imeter single-dish telescopes, millimeter interferometers, and ground-
based as well as space-borne infrared observatories have only become p
ossible within the past few years. Results are compared with detailed
chemical models that emphasize the coupling of gas-phase and grain-sur
face chemistry. Molecules that are particularly sensitive to different
routes of formation and that may be useful in distinguishing between
a variety of environments and histories are outlined. In the cold, low
-density prestellar cores, radicals and long unsaturated carbon chains
are enhanced. During the cold collapse phase, most species freeze out
onto the grains in the high-density inner region. Once young stars ig
nite, their surroundings are heated through radiation and/or shocks, w
hereupon new chemical characteristics appear. Evaporation of ices driv
es, a ''hot core'' chemistry rich in organic molecules, whereas shocks
propagating through the dense envelope release both refractory and vo
latile grain material, resulting in prominent SiO, OH, and H2O emissio
n. The role of future instrumentation in further developing these chem
ical and temporal diagnostics is discussed.