MUTATIONAL ANALYSIS OF F1F0 ATPASE - CATALYSIS AND ENERGY COUPLING

Authors
OMOTE H FUTAI M
Citation
H. Omote et M. Futai, MUTATIONAL ANALYSIS OF F1F0 ATPASE - CATALYSIS AND ENERGY COUPLING, Acta Physiologica Scandinavica, 163, 1998, pp. 177-183
Citations number
33
Categorie Soggetti
Physiology
Journal title
Acta Physiologica Scandinavica → ACNP
ISSN journal
00016772
Volume
163
Year of publication
1998
Supplement
643
Pages
177 - 183
Database
ISI
SICI code
0001-6772(1998)163:<177:MAOFA->2.0.ZU;2-Z
Abstract
Escherichia coli ATP synthase has eight subunits and functions through transmission of conformational changes between subunits. Extensive mu tational analyses identified essential residues for catalysis and conf ormation transmission. Pseudorevertant studies revealed that beta/alph a and beta/gamma subunits interactions are important for the energy co upling between catalysis and H+ translocation. In this article, we dis cuss mechanism of catalysis and energy coupling based on our recent mu tation studies.