AGGRESSIVE NON-HODGKINS-LYMPHOMA AFTER SUCCESSFUL ERADICATION OF HELICOBACTER-PYLORI AND REGRESSION OF GASTRIC LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE

A 57-year-old woman presented to our clinic with low-grade gastric lym phoma of mucosa-associated lymphoid tissue (stage IE) and Helicobacter pylori infection. She received a 2-week course of omeprazole and clar ithromycin, resulting in eradication of H, pylori and histological dis appearance of the lymphoma. However, 9 months later (May 1996), multip le mass lesions were found around the pancreas and hepato-duodenal lig ament on abdominal computed tomography. Inguinal lymph node biopsy rev ealed aggressive nodal type B-cell non-Hodgkin's lymphoma, diffuse lar ge cell type. She received chemotherapy with cyclophosphamide, adriamy cin, vincristine, and prednisolone, but failed to achieve remission an d died in December 1996. There was no evidence of recurrent gastric ly mphoma. This case emphasizes the importance of performing followup exa minations to detect other neoplasms in patients with gastric lymphoma of mucosa-associated lymphoid tissue.