EFFICACY OF DOSE-INTENSIFIED MEC (METHOTREXATE, EPIRUBICIN AND CISPLATIN) CHEMOTHERAPY FOR ADVANCED UROTHELIAL CARCINOMA - A PROSPECTIVE RANDOMIZED TRIAL COMPARING MEC AND M-VAC (METHOTREXATE, VINBLASTINE, DOXORUBICIN AND CISPLATIN)

Background: To evaluate the antitumor activity in patients with T3b, T 4 or metastatic urothelial carcinoma treated with MEC or M-VAC chemoth erapy, by performing a multi-center randomized prospective study. Meth ods: From 1991 to 1995, 89 patients with T3b, T4 or metastatic urothel ial carcinoma were randomly allocated to a methotrexate, epirubicin an d cisplatin chemotherapy group (arm 1. S-MEC therapy; n = 29), a dose- intensified MEC therapy combined with G-CSF group (arm 2, I-MEG therap y; n = 30) or a methotrexate, vinblastine, doxorubicin and cisplatin c hemotherapy (arm 3. M-VAC therapy; n = 30). At the registration center , the patients were stratified into previously untreated patients and patients with recurrence after radical operation and then randomly all ocated to the treatment groups. In each arm, two or more courses of ch emotherapy (4-week cycles) were performed. Results: Of the 88 eligible patients, four treated with S-MEC therapy and two treated with I-MEG therapy showed CR. The response rates (CR + PR) were 52% (15/29) with S-MEC therapy, 76% (22/29) with I-MEG therapy and 47% (14/30) with M-V AC therapy. The response rate with I-MEG therapy was significantly hig her than that with M-VAC therapy (P = 0.02). Although the incidence of leukopenia was low with I-MEG therapy, the incidence of thrombocytope nia was high with this therapy. Conclusion: MEC therapy used in this s tudy is promising in terms of the antitumor effects.