Increased activity or inadequate inhibition of the autonomic nervous s
ystem is often the cause of perioperative hypertension. The goal of tr
eatment is to maintain an adequate balance between myocardial oxygen s
upply and demand. Newer agents, such as nicardipine and fenoldopam, ma
y offer potential advantages over older agents. The cost:benefit ratio
of therapy with these newer agents must also be considered. Despite t
he fact that perioperative hypertension is aggressively treated, there
are no long-term, large-scale study data indicating that this treatme
nt affects long-term patient outcomes.