PROSPECTIVE FOLLOW-UP OF JAPANESE WOMEN WITH CERVICAL INTRAEPITHELIALNEOPLASIA AND VARIOUS HUMAN-PAPILLOMAVIRUS TYPES

Objective: To evaluate the prevalence of genital human papillomavirus (HPV) types in cervical neoplasias and to evaluate the biological acti vity of individual HPV types in cervical carcinogenesis. Method: Cellu lar samples from 318 patients with cervical intraepithelial neoplasia (CIN) or invasive cervical carcinoma were examined for HPV DNA, using a polymerase chain reaction. Of these, 145 women with CIN grade I or I I were prospectively followed to better understand the natural history of these precancerous lesions. Result: HPV DNA was detected in 88, 80 and 89%, of CIN grade I, II and III, respectively, and in 92% in inva sive carcinomas. The CIN follow-up data showed a significantly higher progression rate in patients with CIN II than in cases of CIN I, and o ur classification of HPV types based on HPV prevalence data correlates well with the prospective follow-up data. A significantly higher prog ression rate was observed in HPV-negative CINs. Conclusion: Classifica tion of HPV types according to risk to a malignant state seems to be p ossible. It seems that I-IPV negative lesions are likely to progress t o a malignant state. (C) 1998 International Federation of Gynecology a nd Obstetrics.