JUVENILE FEMALE LITOMOSOIDES SIGMODONTIS PRODUCE AN EXCRETORY SECRETORY ANTIGEN (JUV-P120) HIGHLY MODIFIED WITH DIMETHYLAMINOETHANOL/

Authors
HINTZ M SCHARES G TAUBERT A GEYER R ZAHNER H STIRM S CONRATHS FJ
Citation
M. Hintz et al., JUVENILE FEMALE LITOMOSOIDES SIGMODONTIS PRODUCE AN EXCRETORY SECRETORY ANTIGEN (JUV-P120) HIGHLY MODIFIED WITH DIMETHYLAMINOETHANOL/, Parasitology, 117, 1998, pp. 265-271
Citations number
30
Categorie Soggetti
Parasitiology
Journal title
Parasitology → ACNP
ISSN journal
00311820
Volume
117
Year of publication
1998
Part
3
Pages
265 - 271
Database
ISI
SICI code
0031-1820(1998)117:<265:JFLSPA>2.0.ZU;2-1
Abstract
A 120 kDa antigen produced by juvenile female Litomosoides sigmodontis (Juv-p120) was isolated and purified. The amino acid composition of t he molecule was determined. Juv-p120 was shown to be highly modified w ith N,N-dimethylaminoethanol (28.4 mol %). Treatment of Juv-p120 with potassium hydroxide (beta-elimination) or with sodium m-periodate lead s to the destruction of epitopes recognized by antibodies immune affin ity-purified with isolated Juv-p120. Juvenile L. sigmodontis were show n to release Juv-p120 into the pleural cavity of infected Mastomys cou cha before the onset of patency.