TRANSLOCATION(1-22) IN REFRACTORY-ANEMIA AND THE PROGNOSTIC-SIGNIFICANCE OF KARYOTYPIC ABNORMALITIES IN REFRACTORY-ANEMIA

Authors
KEUNG YK COBOS E TONK V MORGAN D
Citation
Yk. Keung et al., TRANSLOCATION(1-22) IN REFRACTORY-ANEMIA AND THE PROGNOSTIC-SIGNIFICANCE OF KARYOTYPIC ABNORMALITIES IN REFRACTORY-ANEMIA, Cancer genetics and cytogenetics, 106(1), 1998, pp. 72-75
Citations number
25
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
106
Issue
1
Year of publication
1998
Pages
72 - 75
Database
ISI
SICI code
0165-4608(1998)106:1<72:TIRATP>2.0.ZU;2-T
Abstract
The most common cytogenetic abnormalities associated with myelodysplas tic syndromes are deletions of chromosomes 5 and 7 and trisomy 8. Reci procal translocation is relatively uncommon in refractory anemia. We d escribe a case of refractory anemia associated with trisomy 8 and a de rivative chromosome 22 resulting from t(1;22)(q11;q11.2). The diseases and the role of the various genes that are mapped to these breakpoint s are discussed. The prognostic significance of karyotypic abnormaliti es in refractory anemia are reviewed. (C) Elsevier Science Inc., 1998.