A. Grinshpoon et al., ZUCLOPENTHIXOL, D-1 D-2 ANTAGONIST, FOR TREATMENT OF CHRONIC AGGRESSIVE SCHIZOPHRENIA AND PSYCHOTIC OLIGOPHRENIC PATIENTS/, European psychiatry, 13(5), 1998, pp. 273-275
An open label trial was conducted to study the efficacy of zuclopenthi
xol decanoate, a D-1/D-2 antagonist, in the treatment of chronic (> 10
years) neuroleptic-resistant aggressive schizophrenia (n = 10) and ps
ychotic oligophrenic patients (n = 6). A significant reduction was not
ed in the Brief Psychiatric Rating Scale score, especially in the clus
ters of hostility-suspiciousness and excitement. After many years of s
eclusion, ten of the 16 patients were transferred to an open psychiatr
ic department and were allowed to visit their families. (C) 1998 Elsev
ier, Paris.