CONCENTRATIONS OF CEFODIZIME IN BRONCHIAL-SECRETIONS AFTER SINGLE INTRAVENOUS ADMINISTRATION

The concentrations of cefodizime (HR 221, CAS 69739-16-8) in bronchial secretions were measured after administration of a single intravenous bolus of 2 g in 19 patients requiring fibreoptic bronchoscopy for dia gnostic purposes or as therapeutic follow-up. These concentrations, wh ich were obtained in absence of inflammation of the mucosa, were compa red to serum concentrations obtained simultaneously. The penetration i nto bronchial secretions was rapid, maximum levels of between 1 and 5 mg/kg being already observed 1 h after injection. Most concentrations remained about 1 mg/kg throughout the whole observation period of abou t 5.5 h. The percent penetration amounted to about 1.5 % of the corres ponding serum concentrations. Conclusion: Concentrations well above th e MIC90s of the relevant respiratory pathogens - S. pneumoniae, M. cat arrhalis, H. influenzae, K pneumoniae - and Enterobacteriaceae were re ached in bronchial secretions after intravenous injection of a single 2 g dose of cefodizime. Even higher levels may be expected in the usua l condition of inflamed bronchial mucosa as found in respiratory infec tions.