MAPPING OF THE GENE FOR INTERFERON-INDUCIBLE DSRNA-DEPENDENT PROTEIN-KINASE TO CHROMOSOME REGION 2P21-22 - A SITE OF REARRANGEMENTS IN MYELOPROLIFERATIVE DISORDERS

Recent evidence suggests that the human interferon-inducible double-st randed RNA-dependent protein kinase may function as a tumor suppressor . Here we describe the mapping of the gene for this kinase to chromoso me region 2p21-22 by fluorescence in situ hybridization. A combined an alysis of cytogenetic data from a series of 341 patients with hematolo gic disorders that exhibited cytogenetic abnormalities and from publis hed reports indicates that abnormalities involving 2p21-22 occur nonra ndomly and are observed among patients with acute myelogenous leukemia , raising the possibility of a role for this protein kinase in leukemo genesis. (C) 1993 Wiley-Liss, Inc.