NICOTINE AVAILABILITY FROM ECLIPSE TOBACCO-HEATING CIGARETTE

A cigarette which heats rather than bums tobacco (Premier) was introdu ced in 1988, but was unacceptable due to unpleasant taste and low nico tine intake, We examined availability of nicotine from a new version ( Eclipse). in the same four subjects as our earlier Premier study. Aver age blood nicotine boosts of 23.7 and 17.8 ng/ml were obtained from sm oking a first and second Eclipse. This substantially exceeds intake fr om Premier (boost 13 ng/ml) and that obtained by heavy smokers from co nventional brands (boost 12-15 ng/ml). Eclipse (or similar product) ma y be the best option for averting Peto's dire warnings of rising milli ons of annual smelting deaths in the 2020 s, and its potential for lar ge-scale, long-term switching warrants further study.