We report two infants with eosinophilic gastroenteritis (EG). This rar
e disease can mimic the clinical symptoms and US appearance of idiopat
hic hypertrophic pyloric stenosis (IHPS). US examination of the antrop
yloric region with a high-frequency linear transducer can assist in th
e differentiation of EG from IHPS, which is important because the ther
apeutic approaches are completely different. Eosinophilic gastroenteri
tis should be considered in the differential diagnosis of IHPS, especi
ally when there has been an ineffective pyloromyotomy.