EFFECT OF ROTATIONAL CORONARY ATHERECTOMY ON PERIPHERAL ENDOTHELIN-1,ATRIAL-NATRIURETIC-PEPTIDE, AND CYCLIC ADENOSINE-MONOPHOSPHATE PLASMA-LEVELS

We investigated the effects of coronary rotational atherectomy (PTCRA) on plasma levels of endothelin-1 (ET-1), atrial natriuretic peptide ( ANP), and cyclic adenosine monophosphate (cAMP). We studied 14 patient s undergoing PTCRA and compared them with 14 patients undergoing plain balloon angioplasty. Blood samples were taken from the femoral vein a t baseline, after the end of the atherectomy, after the first balloon inflation, after the end of the procedure, and 4 hours later. ET-1 inc reased in the angioplasty group from 6.3 +/- 3.2 pmol/L at baseline to 8.5 +/- 3.9 pmol/L at the end of the procedure (F = 3.83, P = .02), w hereas it did not change in the PTCRA group. ANP increased in the PTCR A group from 78.1 +/- 15.7 pmol/L at baseline to 89.7 +/- 24.0 pmol/L at the end of the procedure (F = 6.75, P = .0001), whereas it did not change in the angioplasty group. cAMP decreased in the PTCRA group, wh ereas it did not change in the angioplasty group. In conclusion, ET-1 increases less, ANP increases more, and cAMP decreases more during ath erectomy than during plain balloon angioplasty.